Reviews in Cardiovascular Medicine

RICM _v15n3_14

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CONTRIBUTORS Christopher P Cannon, MD, FACC %S$BOOPOJTB1SPGFTTPSPG.FEJDJOFBU)BSWBSE.FEJDBM4DIPPMBOEB)FJTBTFOJPS JOWFTUJHBUPSJOUIF5ISPNCPMZTJT*O.ZPDBSEJBM*OGBSDUJPO 5*.* 4UVEZ(SPVQJOUIF $BSEJPWBTDVMBS%JWJTJPOBU#SJHIBNBOE8PNFOlT)PTQJUBMJO#PTUPO)FIBTPSJTMFBE JOHJOUFSOBUJPOBMUSJBMTJOUIFGJFMEPGBDVUFDPSPOBSZTZOESPNFTBOEQSFWFOUJPO)FJT &EJUPSJO$IJFGPGUIFKPVSOBMCritical Pathways in CardiologyBOE%FQVUZ&EJUPSJO$IJFG PGClinical CardiologyBTXFMMBT&EJUPSJO$IJFGPG$BSEJP4PVSDF4DJFODFBOE2VBMJUZUIF "NFSJDBO$PMMFHFPG$BSEJPMPHZlT8FCTJUF XXXDBSEJPTPVSDFPSH Prakash C Deedwania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rediman K Shah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lice K Jacobs, MD, FACC, FAHA %S+BDPCTJTB1SPGFTTPSPG.FEJDJOFBU#PTUPO6OJWFSTJUZ4DIPPMPG.FEJDJOFBOE UIF%JSFDUPSPG*OWBTJWF$BSEJPMPHZ4FSWJDFTBU#PTUPO.FEJDBM$FOUFS)FSNBKPS SFTFBSDIJOUFSFTUJTJODPSPOBSZSFWBTDVMBSJ[BUJPOTUSBUFHJFT%S+BDPCTJTUIFQSJODJQBM JOWFTUJHBUPSPGUIF."44$0..USJBMXIJDIJTFWBMVBUJOHUIFTBGFUZBOEFGGJDBDZ PGDPSPOBSZBOHJPQMBTUZQFSGPSNFEJODPNNVOJUZIPTQJUBMTXJUIPVUPOTJUFDBSEJBD TVSHFSZJO.BTTBDIVTFUUT4IFJTBMTPJOUFSFTUFEJODBSEJPWBTDVMBSEJTFBTFJOXPNFO BOEUIFTFYCBTFEEJGGFSFODFTJOUIFFQJEFNJPMPHZEJBHOPTJTUSFBUNFOUBOEQSPHOPTJT PGJTDIFNJDIFBSUEJTFBTF Matthew J Price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erald M Pohost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ean J Kereiakes, MD, FACC, FSCAI "OBDUJWFDMJOJDBMBOETDJFOUJGJDJOWFTUJHBUPS%S,FSFJBLFTJT.FEJDBM%JSFDUPSPG5IF $ISJTU)PTQJUBM)FBSUBOE7BTDVMBS$FOUFSBOE5IF-JOEOFS$FOUFSGPS3FTFBSDIBOE &EVDBUJPOBOE1SPGFTTPSPG$MJOJDBM.FEJDJOFBU0IJP4UBUF6OJWFSTJUZ%S,FSFJBLFT TFSWFTPOUIFTDJFOUJGJDBEWJTPSZCPBSETGPSNVMUJQMFNFEJDBMEFWJDFDPNQBOJFTBOE 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$FOUFSJO%BMMBT59)FJTBOJOUFSOBUJPOBMMZSFDPHOJ[FEBVUIPSJUZPOUIFSPMFPGDISPOJDLJEOFZEJTFBTFBTB DBSEJPWBTDVMBSSJTLTUBUFXJUIPWFSQVCMJDBUJPOT%S.D$VMMPVHIIBTXPOOVNFSPVTBXBSETJODMVEJOH JOUIF4JNPO%BDL"XBSEGSPNUIF"NFSJDBO$PMMFHFPG$BSEJPMPHZGPSPVUTUBOEJOHTDIPMBSTIJQBOEUIF *OUFSOBUJPOBM7JDFO[B"XBSEGPS$SJUJDBM$BSF/FQISPMPHZGPSIJTDPOUSJCVUJPOTBOEEFEJDBUJPOUPUIFFNFSHJOH QSPCMFNPGDBSEJPSFOBMTZOESPNFT Norman E Lepor, MD, FACC, FAHA, FSCAI ,OPXOGPSIJTJOUFSFTUJOHSBEVBUFNFEJDBMFEVDBUJPOBOEJOWFTUJHBUJPOTJOUIFGJFMEPG JOUFSWFOUJPOBMDBSEJPMPHZ%S-FQPSJTDPGPVOEFSPGReviews in Cardiovascular Medicine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regg C Fonarow, MD, FACC, FAHA "OFNJOFOUTQFDJBMJTUJOIFBSUGBJMVSFNBOBHFNFOUQSFWFOUJWFDBSEJPMPHZRVBMJUZPGDBSF BOEPVUDPNFTSFTFBSDI%S'POBSPXIPMETUIF&MJPU$PSEBZ$IBJSJO$BSEJPWBTDVMBS.FEJ DJOFBOE4DJFODF)FJTB1SPGFTTPSPG.FEJDJOFJOUIF%JWJTJPOPG$BSEJPMPHZBU5IF%BWJE (FGGFO4DIPPMPG.FEJDJOFBU6$-"%JSFDUPSPGUIF"INBOTPO6$-"$BSEJPNZPQBUIZ $FOUFSBOE$P$IJFGPGUIF6$-"%JWJTJPOPG$BSEJPMPHZ Gregg W Stone, MD, FACC, FSCAI %S4UPOFJT1SPGFTTPSPG.FEJDJOFBU$PMVNCJB6OJWFSTJUZ%JSFDUPSPG$BSEJPWBTDVMBS 3FTFBSDIBOE&EVDBUJPOBUUIF$FOUFSGPS*OUFSWFOUJPOBM7BTDVMBS5IFSBQJFTBU$PMVNCJB 6OJWFSTJUZ.FEJDBM$FOUFSBOE$P%JSFDUPSPG.FEJDBM3FTFBSDIBOE&EVDBUJPOBUUIF $BSEJPWBTDVMBS3FTFBSDI'PVOEBUJPOJO/FX:PSL/:%S4UPOFIBTTFSWFEBTUIFMFBE QSJODJQBMJOWFTUJHBUPSGPSNPSFUIBOOBUJPOBMBOEJOUFSOBUJPOBMNVMUJDFOUFSSBOEPN J[FEUSJBMTBOEJTUIF$P%JSFDUPSPG5SBOTDBUIFUFS$BSEJPWBTDVMBS5IFSBQFVUJDTUIF XPSMElTMBSHFTUTZNQPTJVNEFWPUFEUPJOUFSWFOUJPOBMDBSEJPMPHZBOEWBTDVMBSNFEJDJOF Mikhail Kosiborod, MD, FACC, FAHA %S,PTJCPSPEJTBDBSEJPMPHJTUBOEBDMJOJDBMTDIPMBSBU4BJOU-VLFl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illiam T Abraham, MD, FACP, FACC %S"CSBIBNJT1SPGFTTPSPG*OUFSOBM.FEJDJOFBOE$IJFGPGUIF%JWJTJPOPG$BSEJPWBTDVMBS .FEJDJOFBU5IF0IJP4UBUF6OJWFSTJUZJO$PMVNCVT0))FFBSOFEIJTNFEJDBMEFHSFF GSPN)BSWBSE6OJWFSTJUZBOEDPNQMFUFEQPTUHSBEVBUFUSBJOJOHBUUIF6OJWFSTJUZPG$PMP 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Gordon, MD, FACC +PIO(PSEPOJTJOQSJWBUFQSBDUJDFBOEBQBSUOFSBUUIF4BO%JFHP$BSEJBD$FOUFS.FEJ DBM(SPVQXIJDIIFKPJOFEJO)FJTBTFOJPSJOUFSWFOUJPOBMDBSEJPMPHJTUBU4IBSQ .FNPSJBM)PTQJUBMXIFSFIFMBVODIFEUIFQFSJQIFSBMJOUFSWFOUJPOTQSPHSBNJOUIF $BSEJBD$BUIFUFSJ[BUJPO-BCPSBUPSZBOEUIF4IBSQ.FNPSJBM45&.*QSPHSBN)FIBT TFSWFEBT$IJFGPGUIF$BSEJPMPHZ4VCTFDUJPOBOE7JDF$IBJSPGUIF*OUFSOBM.FEJDJOF

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